17alpha-Hydroxyprogesterone (C15-1258-136)

Catalog No.: C15-1258-136
Manufacturer No.: H5752-5G
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: GR

Price: $204.21

List Price: $226.90

17α-Hydroxyprogesterone (17OHP) is a cortisol precursor and is synthesized from progesterone by the action of enzyme 17α-hydroxylase. 17OHP is a poor ligand for the nuclear progesterone receptor and an antagonist for mineralocorticoid

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Description
Specifications

General description

Application

17α-Hydroxyprogesterone has been used:

for titration against ovarian S9 protein in thin-layer chromatography
as a substrate for hydroxysteroid dehydrogenase from B. megaterium cultures
as a cortisone analog to test its effect on voltage-dependent potassium channels (Kv1)

Biochem/physiol Actions

17α-Hydroxyprogesterone (17OHP) is converted to 11-deoxycortisol in the presence of enzyme 21-hydroxylase. Deficiency of 21-hydroxylase results in the accumulation of 17OHP. High levels of 17OHP are observed in congenital adrenal hyperplasia (CAH).

UPC:: 41141902
Condition:: New
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: H5752-5G

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