Application
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(4-piperidinyloxy) Hydrochloride is a functionalized Cereblon ligand used for development of protein degrader building blocks. Contains a terminal amine group, allowing rapid conjugation of carboxyl containing linkers. A basic building block for development of a protein degrader library.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Other Notes
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Legal Information
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Shipping Information:
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- UPC:
- 51172170
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 930717-50MG
- CAS:
- 2640388-58-3
- Temperature Control Device:
- Yes
![1h-isoindole-1 3(2h)-dione 4-[(4-aminobutyl)amino]-2-(2 6-dioxo-3-piperidinyl)- hydrochloride](https://cdn11.bigcommerce.com/s-2u2oi3cvy8/images/stencil/500x659/products/2060964/2069324/cenmed-product-image-placeholder-1-__65020.1734008143.jpg?c=1 "1h-isoindole-1 3(2h)-dione 4-[(4-aminobutyl)amino]-2-(2 6-dioxo-3-piperidinyl)- hydrochloride")
![2-{4-[(1 3-dioxo-1 3-dihydro-2h-isoindol-2-yl)methyl]benzyl}-1h-isoindole-1 3(2h)-dione-](https://cdn11.bigcommerce.com/s-2u2oi3cvy8/images/stencil/500x659/products/1922506/1930867/cenmed-product-image-placeholder-1-__88624.1732301781.jpg?c=1 "2-{4-[(1 3-dioxo-1 3-dihydro-2h-isoindol-2-yl)methyl]benzyl}-1h-isoindole-1 3(2h)-dione-")
![2-{4-[(1 3-dioxo-1 3-dihydro-2h-isoindol-2-yl)methyl]-2 5-dimethylbenzyl}-1h-isoindole-1 3(2h)-dione-](https://cdn11.bigcommerce.com/s-2u2oi3cvy8/images/stencil/500x659/products/1922504/1930865/cenmed-product-image-placeholder-1-__42774.1732301780.jpg?c=1 "2-{4-[(1 3-dioxo-1 3-dihydro-2h-isoindol-2-yl)methyl]-2 5-dimethylbenzyl}-1h-isoindole-1 3(2h)-dione-")
![5-nitro-2-{4-[4-(5-nitro-1 3-dioxo-1 3-dihydro-2h-isoindol-2-yl)benzyl ]phenyl}-1h-isoindole-1 3(2h)-dione](https://cdn11.bigcommerce.com/s-2u2oi3cvy8/images/stencil/500x659/products/1959832/1968193/cenmed-product-image-placeholder-1-__40914.1732562562.jpg?c=1 "5-nitro-2-{4-[4-(5-nitro-1 3-dioxo-1 3-dihydro-2h-isoindol-2-yl)benzyl ]phenyl}-1h-isoindole-1 3(2h)-dione")
