2',3'-cGAMP Sodium Salt (C09-0823-211)

Information2',3'-cGAMP Sodium Salt 2',3'-cGAMP Sodium Salt (2'-3'-cyclic GMP-AMP Sodium) is produced in response to DNA in the cytoplasm in mammalian cells and binds STING with high affinity and is an effective inducer of interferon-β (IFNβ) . 2',3'-cGAMP binds to STING with Kd of 3.79 nM.TargetsSTING (Cell-free assay) 3.79 nM(Kd)In vitro2/',3/'-cGAMP is an endogenous second messenger produced by mammalian cells. 2/',3/'-cGAMP is a high affinity ligand for STING. 2/',3/'-cGAMP is a potent inducer of type-I interferons. 2/',3/'-cGAMP binding induces conformational changes of STING.Cell Research(from reference)Cell lines：A549, BSC-40, BSR-T7, Vero cells Concentrations：25 μM, 20 μM, 2.5 μM Incubation Time：30 min. Specification: 0.98 Molecular Formula: C20H22N10Na2O13P2 Molecular Weight: 674.41 (free acid basis) PubChem CID: 135564529 Isomeric SMILES: C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=C3N=C(NC4=O)N)OP(=O)(OC[C@@H]5[C@H]([C@H]([C@@H](O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)O)O)O