Name: 2 5-DIOXOPYRROLIDIN-1-YL (2 5-DICHLOROBENZOYL)GLYCYL-L-LEUCINATE (C15-1313-508)
SKU: C15-1313-508
Price: 304.9 USD
Availability: InStock

2 5-DIOXOPYRROLIDIN-1-YL (2 5-DICHLOROBENZOYL)GLYCYL-L-LEUCINATE (C15-1313-508)

Catalog No.

C15-1313-508

Manufacturer No.

930237-250MG

Manufacturer Name

Sigma-Aldrich

Quantity

250

Unit of Measure

Price: $304.90

List Price: $338.78

Application CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and

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Description
Specifications

Application

CANDDY (Chemical knockdown with Affinity aNd Degradation DYnamics) employs a bispecific molecule (target interactor + linker + CANDDY_MLN) that degrades protein by direct recruitment to the proteasome. Shown to selectively and dose-dependently degrade KRAS G12D/V and MDM2 proteins and suppress their signaling without non-specific cytotoxic effects.

CANDDY, a protein-slaying approach, occurs without ubiquitination and bypasses the need for an E3 ligase. Has the potential to overcome the current limitations of proteolysis and to expand the application scope of degraders.

Molecular Weight: 458.29. Empirical Formula: C₁₉H₂₁Cl₂N₃O₆. Quality Level: 100. Assay: ≥. 95%. form: powder. storage temp.: 2-8Â°C. SMILES string: ClC1: CC: C(Cl)C(C(NCC(N[C@H](C(ON2C(CCC2: O): O): O)CC(C)C): O): O): C1. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.