![2-[6-(3-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}propoxy)pyridin-3-yl]acetic acid (c15-1313-309)](https://cdn11.bigcommerce.com/s-2u2oi3cvy8/images/stencil/1280x1280/products/1141923/966639/cenmed-product-image-placeholder-1-__85476.1717750017.jpg?c=1 "2-[6-(3-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}propoxy)pyridin-3-yl]acetic acid (c15-1313-309)")
Application
2-[6-(3-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}propoxy)pyridin-3-yl]acetic acid is a heterobifunctional crosslinker useful for development of PROTAC degraders for targeted protein degradation or other bifunctional molecules in chemical biology. Incorporation of rigidity into the linker region may impact the 3D orientation of the molecules and thus ternary complex formation as well as optimization of drug-like properties. For linkers already conjugated to E3 ligase ligands, please visit our collection of Protein Degrader Building Blocks.
Other Notes
Crosslinkers for Bioconjugation
Building PROTAC® Degraders for Targeted Protein Degradation
Technology Article: Degrader Building Blocks for Targeted Protein Degradation
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Molecular Weight: 379.45. Empirical Formula: C19H29N3O5. Quality Level: 100. Assay: ≥. 95%. form: powder. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51294400
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 927694-250MG
![2-[6-(3-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}propoxy)pyridin-3-yl]acetic acid (c15-1313-308)](https://cdn11.bigcommerce.com/s-2u2oi3cvy8/images/stencil/500x659/products/1141922/966638/cenmed-product-image-placeholder-1-__51515.1717750016.jpg?c=1 "2-[6-(3-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}propoxy)pyridin-3-yl]acetic acid (c15-1313-308)")
![5-{4-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2-carboxylic acid (c15-1313-355)](https://cdn11.bigcommerce.com/s-2u2oi3cvy8/images/stencil/500x659/products/1141969/966685/cenmed-product-image-placeholder-1-__61068.1717750029.jpg?c=1 "5-{4-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2-carboxylic acid (c15-1313-355)")
![5-{4-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2-carboxylic acid (c15-1313-354)](https://cdn11.bigcommerce.com/s-2u2oi3cvy8/images/stencil/500x659/products/1141968/966684/cenmed-product-image-placeholder-1-__20142.1717750029.jpg?c=1 "5-{4-[2-(2-{[(tert-butoxy)carbonyl]amino}ethoxy)ethyl]piperazin-1-yl}pyrimidine-2-carboxylic acid (c15-1313-354)")
![2-(6-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-5-oxa-2-azaspiro[3.4]octan-2-yl)acetic acid (c15-1313-101)](https://cdn11.bigcommerce.com/s-2u2oi3cvy8/images/stencil/500x659/products/1141715/966431/cenmed-product-image-placeholder-1-__63127.1717749962.jpg?c=1 "2-(6-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)-5-oxa-2-azaspiro[3.4]octan-2-yl)acetic acid (c15-1313-101)")
