General description
A reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cell lines. Also available as a 25 mM solution in DMSO (Cat. No. 508437).
A reversible inhibitor of aspartic proteases. Inhibits cathepsin D, pepsin, and renin. Reported to block apoptosis induced by CA-074 (Cat. No. 205530) in PC12 cells. Effective concentration: 1 µM.
Effective concentration: 1.0 µM.
Biochem/physiol Actions
EC50 = 1.0 µM in blocking apoptosis induced by CA-074 in PC12 cell lines
Primary Target
cathepsin D
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Other Notes
Isahara, K., et al. 1999. Neuroscience91, 233.
Kanamori, S., et al. 1998. Biochem. Biophys. Res. Commun.251, 204.
Szewczuk, Z., et al. 1992. Int. J. Pept. Prot. Res.40, 233.
Carraway, R.E., et al. 1991. Peptides12, 107.
Eid, M., et al. 1981. Biochem. J.197, 465.
Umezawa, H., et al. 1970. J. Antibiot.23, 259.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51472901
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 516481-100MG