2-Aminoethyl diphenylborinate (C09-0713-785)

2-APB is a transient receptor potential (TRP) activator. The compound also directly blocks the mitochondrial permeability transition pore, sarco/endoplasmic reticulum Ca2+-ATPase pumps, and native store operated channels, as well as other ion channels. 2-APB does not activate the subfamily transient receptor potential vanilloids (TRPVs) TRPV4, TRPV5, and TRPV6, but can activate VR1 (TRPV1), VRL-1 (TRPV2), and TRPV3. 2-ABP was first used as an inhibitor of IP3R (inositol 1,4,5-triphosphate receptor) with the ability to permeate the membrane. 2-ABP can induce Ca2+entry without activating exocytosis. In pancreatic acinar cells 2-ABP can inhibit calcium mobilization. 2-APB is an activator of Orai3. Specification: 0.98 MDL Number: MFCD00014823 Molecular Formula: C14H16BNO Molecular Weight: 225.09 EC Number: 208-366-5 PubChem CID: 1598 Isomeric SMILES: B(C1=CC=CC=C1)(C2=CC=CC=C2)OCCN Beilstein Registry Number: 2942273 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A106408-SCI_b0de3ea891b3e51df6d4969a0839c9ff.pdf