General description
2-Bromobenzaldehyde is a versatile building block used in Suzuki-Miyaura and Buchwald-Hartwig reactions, cross-coupling reactions to form carbon-carbon or carbon-heteroatom bonds
Application
Synthetic applications of 2-bromobenzaldehyde include:
- Synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction.
- Preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.
- It is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.
- Palladium/copper-catalyzed coupling and cyclization of terminal acetylenes derived from 2-bromobenzaldehyde and unsaturated imines can be used in the synthesis of wide range of isoquinolines, including decumbenine B.
- Fluoren-9-ones can be synthesized by annulation of arynes, generated in situ from 2-(trimethylsilyl)aryl triflates, with 2-bromobenzaldehyde in the presence of palladium(0) catalyst.
- It can also be used to build a variety of steroid frameworks, in which ring A is derived from 2-bromobenzaldehyde.
- UPC:
- 51343200
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- B57001-10G
- CAS:
- 6630-33-7
