Application
2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as "undruggable," or difficult-to-target, proteins. This fragment electrophile, or "scout" fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC® molecules for targeted protein degradation as demonstrated by the Cravatt Lab Lab for E3 ligase discovery.
Other Notes
Technology Spotlight: Proteomic Ligandability Assessment
The Proteome-Wide Potential for Reversible Covalency at Cysteine
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16
Proteome-wide covalent ligand discovery in native biological systems
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
- UPC:
- 51101640
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 912131-100MG