General description
Hyperacid-labile ester protecting group [1]. Introduced under extremely mild conditions by reacting together the acid, trityl chloride and DIPEA in DCM. Ideal for the protection of the C-terminal carboxylic acid group of C-terminal protected peptide fragments, monoprotection of diacids and as a general carboxylic acid protecting group in organic synthesis.
Associated Protocols and Technical Articles
Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS
Literature references
[1] P. Athanassopoulos, et al. (1995) Tetrahedron Lett., 36, 5645.
Linkage
Replaces: 01-63-0045
Analysis Note
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Melting range (lower value): ≥ 133 °C
Melting range (upper value): ≤ 137 °C
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51434106
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 8510610025
