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2'-deoxyuridine 5'-monophosphate disodium salt (c15-1238-608)

2'-Deoxyuridine 5'-monophosphate disodium salt (C15-1238-608)

Catalog No.
C15-1238-608
Manufacturer No.
D3876-100MG
Manufacturer Name
Sigma-Aldrich
Quantity
100
Unit of Measure
MG
Price: $470.20
List Price: $522.45

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). Application 2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme

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General description

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).

Application

2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.

2′-Deoxyuridine 5′-monophosphate disodium salt has been used:

  • in ultraperformance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) assay
  • to stimulate proliferation of peripheral blood mononuclear cell (PBMCs) exposed to influenza virus antigen
  • in thymidylate synthase activity assay Helicobacter pylori

Biochem/physiol Actions

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

UPC:
51422359
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
D3876-100MG


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