2-HYDROXYETHYL CELLULOSE AVERAGE MV CA. 1 300 000 (C15-1303-529)

General description

ERG is a member of the erythroblastosis virus E26 transforming sequence (ETS) transcription factor gene family, which also includes Fli-1 and ETS-1.^1-5 ERG is expressed in lymphocytes and endothelial cells and regulates endothelial apoptosis and angiogenesis. ERG has been found to be expressed in both benign and malignant vascular tumors. Anti-ERG was found to have high sensitivity for vascular neoplasms.¹ ERG expression has been observed in prostate carcinomas and high-grade prostatic intraepithelial neoplasia (HGPIN).^1-4 ERG positivity in any other epithelial tumor other than prostate carcinoma is extremely rare. In a study of all carcinomas of the breast, gastrointestinal tract, gynecologic system, kidney, lung, ovary, pancreas, salivary glands, skin, thyroid, and testis were negative for ERG.¹ ERG has also been observed to be positive in a minority of Ewing sarcomas.² This is caused by a chromosomal rearrangement which fuses the EWSR1 gene with the ERG gene (EWSR 1:ERG).⁵ ERG has also been observed to stain some meningiomas due to cross reactivity with Fli-1.¹

Quality

IVD

IVD

IVD

RUO

Linkage

ERG Positive Control Slides, Product No. 434S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Sigma-Aldrich Co. LLC

biological source: rabbit. Quality Level: 100, 500. conjugate: unconjugated. antibody form: culture supernatant. antibody product type: primary antibodies. clone: EP111, monoclonal. description: (For In Vitro Diagnostic Use in Select Regions (See Chart)). form: buffered aqueous solution. species reactivity: human. packaging: vial of 0.1 . mL concentrate (434R-14), vial of 0.5 . mL concentrate (434R-15), bottle of 1.0 . mL predilute (434R-17), vial of 1.0 . mL concentrate (434R-16), bottle of 7.0 . mL predilute (434R-18). manufacturer/tradename: Cell Marque^™. . technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200. isotype: IgG. control: tonsil. shipped in: wet ice. storage temp.: 2-8°C. visualization: nuclear. Gene Information: human ... ERG(2078).