25CN-NBOH HYDROCHLORIDE (C005B-309069)

Catalog No.: C005B-309069
Mfr. No.: SML3390-50MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $1,852.15

List Price: $2,057.94

Biochem/physiol Actions 25CN-NBOH is a brain-penetrant, highly potent and selective 5-HT2A receptor agonist (human 2A/rat 2C Ki = 1.3/132 nM: human 2A/2C PI turnover EC50 = 2.

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Description
Specifications

Biochem/physiol Actions

25CN-NBOH is a brain-penetrant, highly potent and selective 5-HT2A receptor agonist (human 2A/rat 2C Ki = 1.3/132 nM; human 2A/2C PI turnover EC50 = 2.1/190 nM) with much reduced efficacy toward human 2B & 2C subtypes (Ki ratio: 2C/2A = 52-81 & 2B/2A = 37; Ca2+ mobilization Δlog(Rmax/EC50 ratio: 2C/2A = 30-180 & 2B/2A = 54; 2C/2A PI turnover EC50 ratio = 81-146) and other receptors/transporters/kinases. When administered in mice in vivo (1, 3, 6 mg/kg s.c.), 25CN-NBOH produces hallucinogen-like effects blockable by 5-HT2A antagonist M100907, but not 5-HT2C antagonist RS102221.

Caution

Hygroscopic

UPC:: 51152061
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3390-50MG
CAS:: 1539266-32-4

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