2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC 50 of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB ( HY-12495 )In VitroPrimary fibroblast lysates from R191H embryos has lower GEF activity than WT lysates, and 2BAct enhances this activity threefold (EC 50 =7.3 nM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.In Vivo2BAct (300 μg 2BAct/g of meal; 21 weeks) normalizes body weight gain in VWM mice . ?/n2BAct prevents the appearance of motor deficits, myelin loss and reactive gliosis in VWM mice . ?/n2BAct stimulates the remaining activity of mutant eIF2B complex in vivo, abrogating the maladaptive stress response . MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:eIF2. Specification: 0.99 Molecular Formula: C19H16ClF3N4O3 Molecular Weight: 440.8 PubChem CID: 132091799
- UPC:
- 51202411
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- B646808-10mg
- CAS:
- 2143542-28-1
- Product Size:
- 10mg
