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3-(([1 1'-biphenyl]-4-ylmethyl)thio)-6-methyl-1 2 4 5-tetrazine (c15-1224-902)

3-(([1 1'-BIPHENYL]-4-YLMETHYL)THIO)-6-METHYL-1 2 4 5-TETRAZINE (C15-1224-902)

Sigma-Aldrich

Catalog No.
C15-1224-902
Manufacturer No.
919950-500MG
Manufacturer Name
Sigma-Aldrich
Quantity
500
Unit of Measure
MG
Price: $602.57
List Price: $669.52

Application 3-(([1,1′-Biphenyl]-4-ylmethyl)thio)-6-methyl-1,2,4,5-tetrazine ( b -Tz) is a minimal tetrazine derivative capable of undergoing [4+2] Diels-Alder cycloaddition reactions with strained alkenes, which makes it highly useful in

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Application

3-(([1,1′-Biphenyl]-4-ylmethyl)thio)-6-methyl-1,2,4,5-tetrazine (b-Tz) is a minimal tetrazine derivative capable of undergoing [4+2] Diels-Alder cycloaddition reactions with strained alkenes, which makes it highly useful in bioorthogonal labeling and cell detection applications. Tetrazines are often incorporated into chemical probes or other small-molecule tools using linkers that may impact physicochemical properties or the performance of the resulting conjugate product. Here, Lambert et al demonstrated the linker-free incorporation of b-Tz via silver-mediated Liebeskind-Srogl cross-coupling with a variety of aryl and heteroaryl boronic acids. This ″minimal″ tetrazine approach will facilitate the introduction of tetrazine into diverse complex molecules and improved probes for live-cell imaging and in vivo chemistry.

Supporting products
PdCl2(dppf): 697230
Ag2O: 226831

Other Notes

Installation of Minimal Tetrazines through Silver-Mediated Liebeskind-Srogl Coupling with Arylboronic Acids

UPC:
51332875
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
919950-500MG


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