![3-[1 3-dihydro-4-(5-hydroxy-1-pentyn-1-yl)-1-oxo-2h-isoindol-2-yl]-2 6-piperidinedione](https://cdn11.bigcommerce.com/s-2u2oi3cvy8/images/stencil/1280x1280/products/847607/675536/cenmed-product-image-placeholder-1-__63468.1717444439.jpg?c=1 "3-[1 3-dihydro-4-(5-hydroxy-1-pentyn-1-yl)-1-oxo-2h-isoindol-2-yl]-2 6-piperidinedione")
Application
3-[1,3-Dihydro-4-(5-hydroxy-1-pentyn-1-yl)-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione is a functionalized cereblon (CRBN) ligand used in the development of lenalidomide-based protein degrader building blocks. Can be activated by many nucleophiles or form ether linkages through its terminal hydroxyl group. A basic building block for development of a protein degrader library.
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Protein Degrader Building Blocks
Other Notes
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Legal Information
PROTAC®
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
- UPC:
- 51372300
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 930822-50MG
![3-[1 3-dihydro-4-(4-hydroxy-1-butyn-1-yl)-1-oxo-2h-isoindol-2-yl]-2 6-piperidinedione](https://cdn11.bigcommerce.com/s-2u2oi3cvy8/images/stencil/500x659/products/848176/676105/cenmed-product-image-placeholder-1-__61795.1717444651.jpg?c=1 "3-[1 3-dihydro-4-(4-hydroxy-1-butyn-1-yl)-1-oxo-2h-isoindol-2-yl]-2 6-piperidinedione")
