3-Amino-1,2,4-triazole (C09-0713-923)

3-Amino-1,2,4-triazole is a small molecule irreversible inhibitor of catalase, an enzyme responsible for converting cellular H2O2 into H2O and O2. Impeding the natural clearance of H2O2 from the cell by catalase has proven useful in studies investigating free radical-mediated damage of cardiac tissue in ischemia. 3-Amino-1,2,4-triazole also shows inhibition of imidazoleglycerol-phosphate dehydratase (HIS3) activity, which interrupts the biosynthesis of histidines. When 3-Amino-1,2,4-triazole is diazotized, the resulting 3-Diazo-1,2,4-triazole is shown to react specifically with tryptophan at acidic pH, presenting a method for determining the tryptophan content of proteins.3-Amino-1,2,4-triazole has been used:· as an organelle-specific perturbant in human embryonic kidney (HEK293T) cells· as histidine biosynthesis inhibitor in medium for screening co-transformants from yeast two-hybrid interactions· for preservation of midgut sample from honey bee. Specification: 0.96 MDL Number: MFCD00005230 Molecular Formula: C2H4N4 Molecular Weight: 84.08 EC Number: 200-521-5 PubChem CID: 1639 Isomeric SMILES: C1=NNC(=N1)N Beilstein Registry Number: 107687 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A107202-SCI_04ebed2b241d6353f176155d1bac75de.pdf