3-Aminopropionitrile fumarate salt (C15-1222-866)

Catalog No.: C15-1222-866
Manufacturer No.: A3134-5G
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: GR

Price: $227.14

List Price: $252.38

Application 3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor: to inhibit collagen cross-linking during microtissue formation and culture in LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell

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Description
Specifications

Application

3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor:

to inhibit collagen cross-linking during microtissue formation and culture
in LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell line in transwell migration and invasion assay
in lysyl oxidase (LOX) activity assay
to study requirement of LOX activity for inducing hypoxia-inducible factor (HIF)2A-dependent stiffness in mouse organoids

Biochem/physiol Actions

3-Aminopropionitrile (β-Aminopropionitrile (BAPN)) functions as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking.

In mammals, metabolism of 3-aminopropionitrile leads to release of cyanide ions. Metabolic activity is localized in the microsomal fraction of the liver, and is believed to proceed through a free-radical pathway.

UPC:: 51432005
Condition:: New
Weight:: 1.00 Ounces
HazmatClass:: No
WeightUOM:: LB
MPN:: A3134-5G

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