Application
3-Aminopropionitrile fumarate salt has been used as a lysyl oxidase (LOX) inhibitor:
- to inhibit collagen cross-linking during microtissue formation and culture
- in LIM domain only 1 (LMO1)- or vector-expressing BE2C neuroblastoma cell line in transwell migration and invasion assay
- in lysyl oxidase (LOX) activity assay
- to study requirement of LOX activity for inducing hypoxia-inducible factor (HIF)2A-dependent stiffness in mouse organoids
Biochem/physiol Actions
3-Aminopropionitrile (β-Aminopropionitrile (BAPN)) functions as an irreversible inhibitor of lysyl oxidase (LOX), an enzyme involved in collagen cross-linking.
In mammals, metabolism of 3-aminopropionitrile leads to release of cyanide ions. Metabolic activity is localized in the microsomal fraction of the liver, and is believed to proceed through a free-radical pathway.
- UPC:
- 51171639
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- A3134-5G
- CAS:
- 2079-89-2