Information3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selectiveSIRT3inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.TargetsSIRT3 (cell-free); SIRT1 (cell-free); SIRT2 (cell-free) 16 nM; 88 nM; 92 nMIn vitroMelatonin-induced increases in deacetylated-SOD2 expression and SOD2 activity are significantly attenuated by 3-TYP in HepG2 cells exposed to Cd (cadmium).Cell Research(from reference)Cell lines：HepG2 cells Concentrations：50 μM Incubation Time：12 h. Specification: 0.99 Molecular Formula: C7H6N4 Molecular Weight: 146.15 PubChem CID: 9833992 Isomeric SMILES: C1=CC(=CN=C1)C2=NNN=C2 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/T414087-SCI_3dac729fdcfd097907073dc491f5a2d3.pdf
- UPC:
- 51162419
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- T414087-5mg
- CAS:
- 120241-79-4
- Product Size:
- 5mg
