Selectively blocks Nav1.6 channels (IC50 = 7.8 nM in Xenopus oocytes versus IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 µM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively).
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Selectively blocks Nav1.6 channels (IC50 = 7.8 nM in Xenopus oocytes versus IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 µM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively).
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