General description 4-Chloro-2-(1 H -pyrazol-3-yl)phenol undergoes Mannich reaction with N,N′: -bis(methoxymethyl)diaza-18-crown-6 to afford NCH 2 N-linked bis(3-(5-chloro-2-hydroxy)pyrazol-1-ylmethyl)-substituted diazacrown ether (98%
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4-Chloro-2-(1H-pyrazol-3-yl)phenol undergoes Mannich reaction with N,N′-bis(methoxymethyl)diaza-18-crown-6 to afford NCH2N-linked bis(3-(5-chloro-2-hydroxy)pyrazol-1-ylmethyl)-substituted diazacrown ether (98% yield).
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