General description
4-Pentynoic acid undergoes copper-catalyzed intramolecular cyclizations to form enol lactones. It also reacts with 1-bromo-1-alkynes in the presence of a Pd catalyst to yield biologically active ynenol lactones.
Application
4-Pentynoic acid was used:
- as building block for the synthesis of library of eight sequence-defined model oligomers
- in one-pot synthesis of the complex polycyclic heterocycles benzo[4,5]imidazo[1,2-c]pyrrolo[1,2-a]quinazolinone derivatives
- in the synthesis of various allenenols lactones [5(E)-(2-allenylidene)-tetrahydro-2-furanones]
- in the synthesis of a cyctotoxic macrolide by ring-closing metathesis of a bis acetylene
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- UPC:
- 51343200
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- MPN:
- 232211-1G
- CAS:
- 1530250