eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, has been shown to amplify TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis via down-regulation of FLIP|S/L|and induction of DR5. These characteristics of the compound seem to be independent of it′s ability to inhibit cap-dependent protein translation which is caused by disruption of the eIF4E/eIF4G association through binding to eIF4E. It has been shown that while 4EGI-1 displaces eIF4G from eIF4E, it consequentially enhances 4E-BP association both|in vivo|and|in vitro|. 4E-BPs regulated the eIF4E/eIF4G complex which has a central role in the regulation of gene expression at the level of translation initiation. Specification: 0.98 Molecular Formula: C18H12Cl2N4O4S Molecular Weight: 451.28 PubChem CID: 5717952 Isomeric SMILES: C1=CC=C(C(=C1)C/C(=N/NC2=NC(=CS2)C3=CC(=C(C=C3)Cl)Cl)/C(=O)O)[N+](=O)[O-] Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/E341874-SCI_b8ef0a7b6227719dcdce9995ef55df34.pdf
- UPC:
- 51111815
- Condition:
- New
- Availability:
- 1 day
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- E341874-1mg
- CAS:
- 315706-13-9
- Product Size:
- 1mg
- Hazard Statement Codes:
- H302
- Precautionary Statement Codes:
- P264:P270
