General description
5- 5-fluoro-2′-deoxyuridylate (FdUMP) is an intracellularly generated metabolite of 5-Fluorouracil (5-FU), a widely used reagent in molecular biology to study DNA synthesis and metabolism.
Application
It has been used:
- as an anti-mitotic agent for culturing mouse primary cortical neurons.
- as a component of feeding media in the culturing of mouse primary cortical neurons.
- in studies on the activity and function of thymidylate synthase (TS).
Biochem/physiol Actions
5-Fluoro-2′-deoxyuridine 5′-monophosphate sodium salt (FdUMP) is an DNA synthesis inhibitor. FdUMP along with RNA synthesis inhibitor 3′-C-ethinylcytidine induces cell death in cervical cancer cells at nanomolar concentrations.
- UPC:
- 51282130
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- F3503-5MG
