5-PH-IAA (C005B-308756)

Catalog No.: C005B-308756
Mfr. No.: SML3574-25MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $613.72

List Price: $681.91

Biochem/physiol Actions 5-Ph-IAA is a bumped auxin-inducible degron (AID) ligand that induces Skp1-Cul1-F-box (SCF) E3 ligase complex-mediated ubiquitinaton of Arabidopsis IAA17-derived mini-AID (mAID) degron-fused target proteins in cells

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Description
Specifications

Biochem/physiol Actions

5-Ph-IAA is a bumped auxin-inducible degron (AID) ligand that induces Skp1-Cul1-F-box (SCF) E3 ligase complex-mediated ubiquitinaton of Arabidopsis IAA17-derived mini-AID (mAID) degron-fused target proteins in cells expressing a hole-modified Oryza sativa TIR1 (OsTIR1) mutant (F74G or F74A). Unlike the traditional AID system, 5-Ph-IAA-based AID2 method shows no detectable leaky degradation, requires a 670-times lower ligand concentration, and achieves quicker degradation in cultures (0.2-5 μM) and in vivo (1-10 mg/kg via daily i.p. to mice xenografted with HCT116 CMV-OsTIR1(F74G) cells expressing mAID-tagged BRD4 or TOP2A).

UPC:: 41116113
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3574-25MG
CAS:: 168649-23-8

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