A natural resorcylic lactone derived from fungi that selectively inhibits purified TAK1 (IC50 = 8.1 nM when co-expressed with the TAK1-binding protein, TAB1); irreversibly blocks IL-1-induced activation of TAK1, NF-κB, and JNK/p38 (IC50s = 65-83 nM) and sensitizes cells to TRAIL- and TNF-α-induced apoptosis in vitro.
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- UPC:
- 51173008
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 17459-5
- CAS:
- 253863-19-3
- Model Number:
- C816R58
- Temperature Control Device:
- Yes