Application
6-((2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptan-6-yl)oxy)pyrimidine-4-carboxylic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.
Similar linkers in this series:
923311
923338
923419
923346
923427
Other Notes
Protein Degrader Building Blocks
Crosslinkers for Bioconjugation
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Molecular Weight: 335.36. Empirical Formula: C16H21N3O5. form: powder or crystals. Quality Level: 100. reaction suitability: reagent type: linker. functional group: Boc, carboxylic acid. storage temp.: 2-8°C. SMILES string: OC(C1: CC(OC2CC3(C2)CN(C(OC(C)(C)C): O)C3): NC: N1): O. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 51294800
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 923370-50MG