6(5H)-Phenanthridinone is a small molecule poly(ADP-ribose) polymerase (PARP) inhibitor with immunosupperessive effects. 6(5H)-Phenanthridinone has been shown to inhibit concanavilin A-induced lymphocyte proliferation, producing the observed immunosuppressant activity of this compound. It has also been shown to potentiate the effect of ionizing radiation on developing cells, strongly increasing the radiation-induced inhibition of cell proliferation, which suggests use of 6(5H)-Phenanthridinone as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis versus treatment with DNA-damaging agents alone, indicating that PARP activity is involved in the apoptotic process.Reactant involved in: Synthesis of 5,6-dihydrophenanthridine sulfonamides. Oxidative coupling with diphenylacetylene. Direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. Reactant involved in the synthesis and/or pharmacological activity of biologically active molecules including: Potassium channel KV1.3 and IK-1 inhibitors. HIV-1 integrase inhibitors. Specification: ≥98.0%(HPLC) MDL Number: MFCD00004988 Molecular Formula: C13H9NO Molecular Weight: 195.22 EC Number: 213-804-3 PubChem CID: 1853 Isomeric SMILES: C1=CC=C2C(=C1)C3=CC=CC=C3NC2=O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/H137937-SCI_287af0bd4bf42f7fed0eba852a615e80.pdf
- UPC:
- 12142207
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 2.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- H137937-5g
- CAS:
- 1015-89-0
- Product Size:
- 5g
