6-Aminocaproic acid (C09-0731-116)

EACA is directly soluble in water at 25 mg/ml. As an inhibitor of plasmin it is has been utilized in the clotting buffer for fibrinogen assays. This buffer is 10 mM potassium and sodium phosphate, pH 6.4, with 0.20 g CaCl2, 5 g 6-Aminohexanoic acid, 1 g sodium azide, and 9 g NaCl in 1 liter. The buffer is stable indefinitely at room temperature.ε-Amino-n-caproic Acid (EACA) is an antifibrinolytic agent shown to enhance the activation of urinary-type and tissue-type plasminogen, while inhibiting plasminogen activation induced by streptokinase through a kringle-dependent mechanism. Believed to act as a lysine analog that competitively inhibits basic carboxypeptidases, and promotes the rapid dissociation of plasmin by inhibiting activation of plasminogen by streptokinase. Incorporation of EACA into short polypeptide fragments with hydrophobic amino acids yielded cytotoxic compounds against MCF-7 breast cells and fibroblast cells. These factors make EACA a potentially useful compound for research in areas such as: oncology, immunology, and in the general elucidation of biochemical pathways.application：6-Aminohexanoic acid is used as an intermediate in the polymerization of Nylon-6. It is involved in the extraction of aldehydes from the reaction mixture as well as to improve the solubilization of membrane proteins in electrophoresis. It acts as an inhibitor of fibrinolysis. Specifications and Purity: 98%. MDL Number: MFCD00008238. Molecular Formula: C6H13NO2. Molecular Weight: 131.17. PubChem CID: 564. Isomeric SMILES: C(CCC(=O)O)CCN. Beilstein Registry Number: 906872. Related Document: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A306000-SCI_4a59dfbc7f96c4f9b1ce264493d16845.pdf