General description
6-Azauridine is a pyrimidine nucleoside analog.
Application
6-Azauridine (AzUrd) blocks the conversion of orotic acid into UMP and it is used in antiviral studies.
6-Azauridine has been used:
- in uridine monophosphate synthase (UMPS) activity assay
- as an antiviral agent to study its inhibition effect and cytotoxic potential on foot and mouth disease virus
- to screen for anticryptosporidial activity
- in the pretreatment of HeLa cells to study its effect on inhibition of cellular uridine synthesis before and during chase with 5-bromouridine 5′-triphosphate (BrUTP)
- as a reference compound for comparing the antiviral activity and cytotoxic activity against viral host cell lines
Biochem/physiol Actions
6-azauridine is a prodrug, upon conversion to 6-aza-UMP, inhibits uridine monophosphate synthase (UMPS). It is a broad spectrum anti-metabolite. It interferes with pyrimidine biosynthesis and affects the cellular nucleic acid levels. It is considered as a antineoplastic metabolite. It inhibits RNA viruses like chikungunya virus, semliki forest virus, and human coronavirus. It significantly inhibits the growth of Cryptosporidium parasites.
- UPC:
- 51285601
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A1882-1G
