6-(N-Trifluoroacetyl)caproic acid NHS

6-(N-Trifluoroacetyl)caproic acid NHS, also known as TCFS, is an amine-reactive modification reagent with a protected primary amine group. It forms amide bonds with primary amines (e.g., lysine side chains) to add a seven-atom spacer arm (7.7 angstroms) terminated by a trifluoroacetyl group that can be removed later to expose a new primary amine. Its benefits lie in its ability to add a protected primary amine group, extend lysine side-chain length to alter steric hindrance and block amine groups and replace them with one on a 7-atom spacer. The leaving group is readily removed unmasking a primary amine capable of reacting with any amine-reactive crosslinker. Specification: ≥98% Molecular Formula: C12H15F3N2O5 Molecular Weight: 324.25 PubChem CID: 3491715 Isomeric SMILES: C1CC(=O)N(C1=O)OC(=O)CCCCCNC(=O)C(F)(F)F Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/N332283-SCI_0c80b5fbb93953661a5b0081d7576171.pdf