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6-THIOGUANINE (C005B-019913)

Catalog No.
C005B-019913
Mfr. No.
A4882-100MG
Mfr. Name
Sigma-Aldrich
Qty/UOM
100
UOM
MG
Price: $148.85
List Price: $165.38

6-Thioguanine is a variant of guanine with hydrogen bonding at the N-7 of the purine ring. Its association with cytosine alters the dimension of the base stacking.

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General description

6-Thioguanine is a variant of guanine with hydrogen bonding at the N-7 of the purine ring. Its association with cytosine alters the dimension of the base stacking. 6-Thioguanine usage in treating inflammatory bowel disease (IBD) contributes to nodular regenerative hyperplasia (NRH) in the liver.

Application

6-Thioguanine has been used:

  • to induce autophagy and apoptosis in colorectal cancer cell lines HCT116
  • as a selection marker in the mutation and survival assay in chinese hamster lung fibroblasts culture V79
  • as a selection marker in clonogenic Lung metastasis assay of 4T1-luc cells

Biochem/physiol Actions

Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.

Antimetabolite used in the treatment of leukemias. Competes with hypoxanthine and guanine for the enzyme hypoxanthine-guanine phosphoribosyltransferase, which catalzyes a critical step in the generation of purine nucleotides.

Shipping Information:

Hazmat Fee: $65.00 + applicable shipping charges are added after the order is placed.

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UPC:
51172308
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
Yes
MPN:
A4882-100MG
CAS:
154-42-7

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