8-iso Prostaglandin E|2|is the epimer at C8 of PGE2 and is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. This compound has been shown to be a potent renal vasoconstrictor in the rat, and to inhibit U-46619 or I-BOP-induced platelet aggregation with IC|50|values of 0.5 and 5 μM, respectively. Interestingly it has been reported that this compound also relaxes smooth muscle and has been shown to cause vasodilation of porcine coronary artery. Furthermore, 8-iso Prostaglandin E|2|demonstrated brochodilation in porcine tracheal smooth muscle via K|+|current suppression caused by activation of thromboxane A2 receptors. Molecular Formula: C20H32O5 Molecular Weight: 352.5 PubChem CID: 5283213 Isomeric SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@H]1C/C=C/CCCC(=O)O)O)O Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/I355894-SCI_cc179cbd01cf5f43a1e0036e72ff4483.pdf
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- I355894-500μg
- CAS:
- 27415-25-4
- Product Size:
- 500μg
- Hazard Statement Codes:
- H302:H361
- Precautionary Statement Codes:
- P201:P202:P264:P270:P281
