8-iso Prostaglandin E|2|-d4 is an isotopically labeled derivative of 8-iso Prostaglandin E|2|, the epimer at C8 of PGE2 and is one of several isoprostanes produced from arachidonic acid during lipid peroxidation. This compound has been shown to be a potent renal vasoconstrictor in the rat, and to inhibit U-46619 or I-BOP-induced platelet aggregation with IC|50|values of 0.5 and 5 μM, respectively. Interestingly it has been reported that this compound also relaxes smooth muscle and has been shown to cause vasodilation of porcine coronary artery. Furthermore, 8-iso Prostaglandin E|2|demonstrated bronchodilation in porcine tracheal smooth muscle via K|+|current suppression caused by activation of thromboxane A2 receptors. Specification: A solution in methanol Molecular Formula: C20H28D4O5 Molecular Weight: 356.5
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- Yes
- WeightUOM:
- LB
- MPN:
- I357330-50μg
- CAS:
- 27415-25-4
- Physical Hazards:
- Flammable Liquid
- Product Size:
- 50μg
