84-B10 (C007B-335893)

84-B10 is a 3-phenylglutaric acid derivative. 84-B10 inhibits cisplatin ( HY-17394 ) induced tubular ferroptosis. 84-B10 attenuates cisplatin-induced mitochondrial damage and oxidative stress. 84-B10 ameliorates cisplatin-induced acute kidney injury (AKI).In Vitro84-B10 (10-100 μM; 2 h) inhibits cisplatin-induced tubular epithelial cell ferroptosis in a dose-dependent manner. 84-B10 (40 μM; 2 h; TKPT cells) restores cisplatin-induced mitochondrial structural damage and dysfunction. 84-B10 (40 μM; 2 h; TKPT cells) attenuates mtROS-induced oxidative stress in cisplatin-induced AKI. 84-B10 (40 μM; 2 h; TKPT cells) attenuates cisplatin-induced epithelial cell injury by eliminating mtROS and restoring mitochondrial homeostasis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: tubular epithelial cell Concentration: 10, 20, 30, 40, 50, and 100 μM Incubation Time: 2 hours Result: Increased the levels of NRF2, SLC7A11, and GPX4 in a dose-dependent manner. Western Blot AnalysisCell Line: TKPT cells Concentration: 40 μM Incubation Time: 2 hours Result: Increased the levels of OM Porins, IMS Cyt c, IM CVa, IM Core 1, and Matrix CypD in a dose-dependent manner.In Vivo84-B10 (5-15 mg/kg; i.p.) alleviates cisplatin-induced acute kidney injury in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male C57BL/6 mice with acute kidney injury Dosage: 5, 10, and 15 mg/kg Administration: intraperitoneal injection Result: Decreased the sCr and BUN levels of cisplatin-exposed mice. Attenuated renal tubules morphological abnormalities in a dose-dependent manner. Decreased NGAL and KIM-1 levels in a dose-dependent manner. Decreased the transcription levels of Lcn2 (which encodes NGAL) and Havcr1.Form:Solid. Specification: 0.99 Molecular Formula: C25H22F3NO5 Molecular Weight: 473.44