9-ING-41 (C09-0927-897)

Information9-ing-41 9-ING-41 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with antitumor activity. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.TargetsGSK-3In vitro9-ING-41, a clinically relevant small molecule GSK-3β inhibitor with broad spectrum pre-clinical antitumor activity, suppresses the growth of neuroblastoma cells. 9-ING-41 induces apoptosis and cell cycle arrest at prophase by targeting centrosomes and microtubule-bound GSK3β.In vivo9-ING-41 has single-agent antitumor activity in a mouse model of MCL. Mouse xenograft studies shows that the combination of clinically relevant doses of CPT-11 and 9-ING-41 lead to greater antitumor effect than is observed with either agent alone.Cell Research(from reference)Cell lines：Neuroblastoma cell lines SK-N-DZ, SK-N-BE Concentrations：0.1 μM–1 μM Incubation Time：48 h. Specification: 0.98 Molecular Formula: C22H13FN2O5 Molecular Weight: 404.35 PubChem CID: 44582816 Isomeric SMILES: CN1C=C(C2=CC3=C(C=C21)OCO3)C4=C(C(=O)NC4=O)C5=COC6=C5C=C(C=C6)F