A-1070722

Catalog No.: C005B-312851
Mfr. No.: SML0863-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $295.70

List Price: $328.55

Biochem/physiol Actions A-1070722 is a potent brain-penetrant inhibitor of glycogen synthase kinase-3 (GSK-3) α: and β: isoforms with a Ki of 0.6 nM for both GSK-3α: and GSK-3β:.

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Description
Specifications

Biochem/physiol Actions

A-1070722 is a potent brain-penetrant inhibitor of glycogen synthase kinase-3 (GSK-3) α and β isoforms with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A-1070722 showed > 50-fold selectivity for GSK-3 over a panel of other kinases tested, including CDK family members. A-1070722 decreased phosphorylation of microtubule-associated protein Tau and protected rat primary cortical neurons against β amyloid and glutamate challenge.

Features and Benefits

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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UPC:: 51172826
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: Yes
MPN:: SML0863-5MG
CAS:: 1384424-80-9

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