InformationA-1331852 A-1331852 is a potent and selective BCL-XL inhibitor with Ki value less than 0.01 nM for BCL-XL and 6 nM, 4 nM, 142 nM for Bcl-2, Bcl-W, MCL-1 respectively. It may be useful in the treatment of cancer, immune and autoimmune diseases.In vitroA-1331852 exhibits remarkable potency both as a single agent and in combination with TKIs in killing primary CD34+ CML cell. Also, It has remarkable potency in inducing apoptosis in these cells at lownanomolar concentrations as early as 1 h post-treatment.In vivoA-1331852 demonstrates antitumor efficacy in the Molt-4 xenograft model, inducing tumor regressions as a single agent.Cell Datacell lines：SH-SY5Y cellsConcentrations：100 nMIncubation Time：0-2 hPowder Purity:≥99%. Specification: 10mM in DMSO Molecular Formula: C38H38N6O3S Molecular Weight: 658.81
- UPC:
- 41116113
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A408788-1ml
- CAS:
- 1430844-80-6
- Product Size:
- 1ml
