A-674563 HYDROCHLORIDE (C005B-309107)

Catalog No.: C005B-309107
Mfr. No.: SML3369-50MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 50
UOM: MG

Price: $255.80

List Price: $284.22

Biochem/physiol Actions A-674563 is an orally available ATP-competitive pan-AKT (PKB, protein Kinase B) inhibitor (AKT1 Ki = 11 nM) with additional potency against PKA, Cdk2 GSK3β: (IC50 = 1.4, 4.

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Description
Specifications

Biochem/physiol Actions

A-674563 is an orally available ATP-competitive pan-AKT (PKB, protein Kinase B) inhibitor (AKT1 Ki = 11 nM) with additional potency against PKA, Cdk2 GSK3β (IC50 = 1.4, 4.2,10 nM, respectively). A-674563 reduces the phosphorylation of cellular Akt substrates (0.1-10 μM; MiaPaCa-2) and enhances paclitaxel efficacy in a PC-3 xenograft model in mice in vivo (40 mg A-674563/kg via p.o. b.i.d. for 21 days, 15 mg paclitaxel/day on days 20, 24, 28).

UPC:: 51262411
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3369-50MG

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