Reversibly inhibits dihyroorotate dehydrogenase, the rate-limiting step in the de novo synthesis of pyrimidines, preventing DNA synthesis of activated lymphocytes (IC50s = 0.09, 3.5, and 12.5 μM for rat, mouse, and human, respectively); also inhibits tyrosine kinases responsible for early T cell and B cell cycling and the production of PGE2, MMP-1, and IL-6 in immune-activated synoviocytes.
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- UPC:
- 51181626
- Condition:
- New
- Availability:
- 3 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 14404-5
- CAS:
- 163451-81-8
- Model Number:
- C828F78
- Temperature Control Device:
- Yes
