A-803467 inhibits spontaneous and evoked action potentials in sensory neurons. It exhibits antinociceptive effects.A-803467 decreases the firing in spinal dorsal horn neurons in vivo.The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models.A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic. Specification: ≥98% MDL Number: MFCD10574689 Molecular Formula: C19H16ClNO4 Molecular Weight: 357.79 PubChem CID: 16038374 Isomeric SMILES: COC1=CC(=CC(=C1)NC(=O)C2=CC=C(O2)C3=CC=C(C=C3)Cl)OC Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A127941-SCI_e65d2bc4dbc677abae7c36b0c8f1e3aa.pdf
- UPC:
- 12352211
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.97 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A127941-50mg
- CAS:
- 944261-79-4
- Product Size:
- 50mg
- Hazard Statement Codes:
- H302
- Precautionary Statement Codes:
- P264:P270:P330:P301+P312:P501
