General description
A metabolically stable and selective P2X purinergic receptor agonist (pEC50 = 5.81) that is shown to be more potent than ATP. Elicits contractions in ileum through the release of endogenous acetylcholine, which can be blocked by tetrodotoxin (~1 mM). Shown to depolarize cells of the longitudinal muscle strips (~ 200 nM to 4 µM) that reaches a peak within 2-3 min after application and then decays to a steady level.
Biochem/physiol Actions
Primary Target
P2X
Reversible: yes
Warning
Toxicity: Standard Handling (A)
Other Notes
Sawyer, G.W., et al. 2000. Br. J. Pharmacol.129, 1458.
Komori, S., et al. 1988. Br. J. Pharmacol.94, 9.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 12352200
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 5054190001
