A1V1PF2-OET (C15-1312-727)

Application

A1V1PF2-OEt is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. An N-terminal variant of A1V1PF2-OEt is also available as BocA1V1PF2 (917478).

A1V1PF2-OEt conjugates are also available for degrader synthesis. Browse our full synthesis offering here: Browse our full synthesis offering here for streamlining SNIPER and PROTAC^® degrader libraries: Degrader Building Blocks

917427 A1V1PF2-OEt-C₆-NH₂ hydrochloride
917672 A1V1PF2-OEt-C₁₀-NH₂ hydrochloride
917923 A1V1PF2-OEt-PEG₁-NH₂ hydrochloride
916676 A1V1PF2-OEt-PEG₃-NH₂ hydrochloride

Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands

Other Notes

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)

SNIPERs−Hijacking IAP activity to induce protein degradation

E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Molecular Weight: 492.58. Empirical Formula: C₂₅H₃₇FN₄O₅. Quality Level: 100. Assay: ≥. 95%. form: powder. reaction suitability: reagent type: ligand. functional group: amine. storage temp.: 2-8°C. SMILES string: N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@H](C(OCC): O)CC2: CC: C(C: C2)F): O): O)C(C)(C)C): O)C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.