Biochem/physiol Actions
ABL2 (or ARG) is a nonreceptor cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of ABL1 and ABL2 includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is involved in translocation with the ETV6 gene in human leukemia and has an altered expression in several human carcinomas. Two isoforms of ABL2 with different N-termini (1A and 1B) have been identified. The C-terminal domain of ABL2 contains two F-actin-binding sequences that perform a number of actions related to cell morphology and motility by interacting with actin filaments.
Physical form
Supplied in 50mM NaPhosphate pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1mM PMSF, 0.2 mM DTT, 25% glycerol.
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Legal Information
PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC
recombinant: expressed in baculovirus infected Sf9 cells. Quality Level: 200. product line: PRECISIO®. Kinase. Assay: ≥. 70% (SDS-PAGE). form: buffered aqueous glycerol solution. specific activity: 1035-1401 . nmol/min·mg. mol wt: ~132 . kDa. UniProt accession no.: P42684. shipped in: dry ice. storage temp.: −. 70°C. Gene Information: human ... ABL2(27). Pictograms: GHS07,GHS08. Signal Word: Danger. Hazard Statements: H315 - H319 - H360D. Precautionary Statements: P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313. Hazard Classifications: Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter.- UPC:
- 51202901
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A0733-10UG
