InformationABTL-0812 ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.TargetsAkt ; mTORIn vitroABTL0812 inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. Furthermore, treatment with ABTL0812 also induces AMPK activation and ROS accumulation. Moreover, combination of ABTL0812 with chemotherapy markedly increases the therapeutic effect of chemotherapy without increasing toxicity. Combination of ABTL0812 and chemotherapy induces nonapoptotic cell death mediated by TRIB3 activation and autophagy induction.In vivoABTL0812 enhances carboplatin and paclitaxel antitumor activity both in adenocarcinomas and squamous lung xenografts.Cell Research(from reference)Cell lines：Human adenocarcinoma cell lines (A549, NCI-H1975), squamous-cell carcinoma (NCI-H520, NCI-H157) Concentrations：0–200 μM Incubation Time：72 h. Specification: 10mM in DMSO Molecular Formula: C18H32O3 Molecular Weight: 296.44 PubChem CID: 21158511 Isomeric SMILES: CCCCC/C=C/C/C=C/CCCCCCC(C(=O)O)O
- UPC:
- 51161564
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A424863-1ml
- CAS:
- 57818-44-7
- Product Size:
- 1ml
