ACH-000143 is a potent and orally active melatonin receptor agonist, with EC 50 values of 0.06 nM and 0.32 nM for MT1 and MT2 , respectivelyIn VivoACH-000143 reduces liver triglycerides and steatosis in diet-Induced obese rats . ACH-000143 is devoid of hERG binding, genotoxicity, and behavioral alterations at doses up to 100 mg/kg p.o., supporting further investigation of this compound as a drug candidate . ACH-000143 significantly reduces plasma glucose at 10 mg/kg (−16.4%, p < 0.05) and 30 mg/kg (−16.9%, p < 0.01) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: High-fat diet rats . Dosage: 10 and 30 mg/kg. Administration: Orally, once daily for two months. Result: Significantly reduced the weekly BW gain on weeks.Form:SolidIC50& Target:MT1 0.06 nM (EC 50 ) MT2 0.32 nM (EC 50 ). Specification: 0.98 Molecular Formula: C13H16ClN3O3 Molecular Weight: 297.74 PubChem CID: 139451790 Isomeric SMILES: CC(=O)NCCN1C2=CC(=C(C=C2N=C1OC)Cl)OC
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A650590-100mg
- CAS:
- 2225836-30-4
- Product Size:
- 100mg
