Acivicin hydrochloride (C09-1103-111)

Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus , is a γ-glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic propertiesIn VitroAcivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days) has an IC 50 of 0.7 μM in human HepG2 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoAcivicin hydrochloride (AT-125 hydrochloride; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to TolueneDosage: 5 mg/kg Administration: IP; twice weekly (monday and wednesday) Result: Reduced urinary γ-GT by 70-78%.IC50& Target:γ-glutamyl transpeptidase. Specifications and Purity: 10mM in DMSO. Molecular Formula: C5H8Cl2N2O3. Molecular Weight: 215.03.