ACRIFLAVINE PURIFIED (C005B-309140)

Catalog No.: C005B-309140
Mfr. No.: SML3350-10MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: EA

Price: $191.26

List Price: $212.52

Biochem/physiol Actions Acriflavine is an antimicrobial drug used to treat against sleeping sickness, urinary tract infections, and gonorrhea. Acriflavine is a potent inhibitor of SARS-CoV-2 papain-5 like protease (PLpro), which potently inhibits

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Biochem/physiol Actions

Acriflavine is an antimicrobial drug used to treat against sleeping sickness, urinary tract infections, and gonorrhea. Acriflavine is a potent inhibitor of SARS-CoV-2 papain-5 like protease (PLpro), which potently inhibits viral replication in vivo in mice and ex vivo in human airway epithelia. It is a mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinium chloride) and proflavine (3,6-diaminoacridine). Apparently commercial acriflavine mixtures contain the combination of differently methylated proflavines to optimally block the PLpro active site. Also, it potently inhibits replication of other betacoronaviruses.

UPC:: 51161541
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML3350-10MG

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