General description
Nitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
Biochem/physiol Actions
EC50 = 130 nM in relaxation of isolated bovine coronary artery rings
Primary Target
Nitric oxide donor
Warning
Toxicity: Irritant (B)
Reconstitution
SNAP evolves NO immediately upon solubilization; reconstitute just prior to use.
Other Notes
Nishio, E., et al. 1996. Biochem. Biophys. Res. Commun.221, 163.
Askew, S.C., et al. 1995. Bioorg. Med. Chem.3, 1.
Fehsel, K., et al. 1995. J. Immunol.155, 2858.
Gopalkrishna, R., et al. 1993. J. Biol. Chem.268, 27180.
Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther.248, 762.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51111621
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 487910-1SET
- Product Size:
- 1SET
- CAS:
- 79032-48-7
