General description
Chemical structure: peptide
Application
Actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes. Actinomycin induces apoptosis and is used as a potent antitumor agent .
Biochem/physiol Actions
An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and in banding techniques to differentiate between different regions of chromosomes.
Actinomycin D is an antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent.
An antineoplastic antibiotic that inhibits cell proliferation by forming a stable complex with DNA and blocking the movement of RNA polymerase which interferes with DNA-dependent RNA synthesis. Induces apoptosis. Potent antitumor agent. For cell culture applications, actinomycin D is used as a selection agent and is used in banding techniques to differentiate between different regions of chromosomes.
Components
1 mg actinomycin D and 49 mg mannitol per vial
Other Notes
The powder is hygroscopic and sensitive to light.
biological source: Streptomyces sp.. Quality Level: 200. form: lyophilized powder. color: yellow to orange. solubility: H2O: 20 . mg/mL. antibiotic activity spectrum: neoplastics. Mode of action: DNA synthesis | interferes. storage temp.: 2-8°C. SMILES string: OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(C)[C@H]1NC(: O)[C@@H](NC(: O)c2ccc(C)c3OC4: CC(: O)C(N): C(C(: O)N[C@H]5[C@@H](C)OC(: O)[C@H](C(C)C)N(C)C(: O)CN(C)C(: O)[C@@H]6CCCN6C(: O)[C@H](NC5: O)C(C)C)C4: Nc23)[C@@H](C)OC(: O)[C@H](C(C)C)N(C)C(: O)CN(C)C(: O)[C@@H]7CCCN7C1: O. InChI: 1S/C61H84N12O16.C6H14O6/c1-27(2)43-58(83)72-22-16-18-35(72)56(81)68(12)25-39(75)70(14)49(29(5)6)60(85)87-32(10)45(54(79)64-43)66-52(77)34-21-20-31(9)51-47(34)63-48-38(89-51)24-37(74)42(62)41(48)53(78)67-46-33(11)88-61(86)50(30(7)8)71(15)40(76)26-69(13)57(82)36-19-17-23-73(36)59(84)44(28(3)4)65-55(46)80. 7-1-3(9)5(11)6(12)4(10)2-8/h20-21,24,27-30,32-33,35-36,43-46,49-50H,16-19,22-23,25-26,62H2,1-15H3,(H,64,79)(H,65,80)(H,66,77)(H,67,78). 3-12H,1-2H2/t32-,33-,35+,36+,43-,44-,45+,46+,49+,50+. 3-,4-,5-,6-/m11/s1. InChI key: AURFRHZIDSMTRK-CSXPNASWSA-N. Pictograms: GHS06,GHS08. Signal Word: Danger. Hazard Statements: H300 - H334 - H351. Precautionary Statements: P201 - P301 + P310 + P330. Hazard Classifications: Acute Tox. 2 Oral - Carc. 2 - Resp. Sens. 1. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges.- UPC:
- 51282001
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A5156-1VL